performance - Optimizing app.yaml -

concerning response time, instance hours , caching efficiency 1 of following configurations efficient google app engine on python 2.7:

config 1

app.yaml:

handlers:  - url: /db/script/.*   script: db/script/crud.app   secure:  - url: /db/state/.*   script: db/state/crud.app   secure:  - url: /db/var/.*   script: db/var/crud.app   secure: 

or config 2

app.yaml:

handlers:  - url: /.*   script: main.app   secure: 

with main.py:

app = webapp2.wsgiapplication([     ('/db/script/.*', db.script.crud),     ('/db/state/.*', db.state.crud),     ('/db/var/.*', db.var.crud) ]) 

regarding performance (response time, instance hours), take here:

• is there performance gain defining routes in app.yaml versus 1 large mapping in wsgiapplication in appengine?

regarding caching, depends on kind of caching thinking of:

• datastore caching happens automatically when use ndb routing setup should not matter.
• browser caching depends on web framework using (e.g. webapp2). can define specific routes static files.
• memcached handled in code , not dependent on routing setup.